α-amino aldehydes as readily available chiral aldehydes for Rh-catalyzed alkyne hydroacylation

Readily available α-amino aldehydes, incorporating a methylthiomethyl (MTM) protecting group on nitrogen, are shown to be efficient substrates in Rh-catalyzed alkyne hydroacylation reactions. The reactions are performed under mild conditions, employing a small-bite-angle bis-phosphine ligand, allowi...

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Bibliografiset tiedot
Päätekijät: Hooper, JF, Seo, S, Truscott, FR, Neuhaus, JD, Willis, MC
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: American Chemical Society 2016