Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1826298819074064384 |
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| author | Cobbold, S Adams, E Farquhar, C Nolan, K Howie, D Lui, K Fairchild, P Mellor, A Ron, D Waldmann, H |
| author_facet | Cobbold, S Adams, E Farquhar, C Nolan, K Howie, D Lui, K Fairchild, P Mellor, A Ron, D Waldmann, H |
| author_sort | Cobbold, S |
| collection | OXFORD |
| description | Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs). T cells fail to proliferate in response to antigen when any 1, or more, of these EAAs are limiting, which is associated with a reduced mammalian target of rapamycin (mTOR) signaling. Inhibition of the mTOR pathway by limiting EAAs, or by specific inhibitors, induces the Treg-specific transcription factor forkhead box P3, which depends on both T cell receptor activation and synergy with TGF-beta. |
| first_indexed | 2024-03-07T04:52:37Z |
| format | Journal article |
| id | oxford-uuid:d57c9241-026c-44bf-96dc-908cafb48f2a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:52:37Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:d57c9241-026c-44bf-96dc-908cafb48f2a2022-03-27T08:26:20ZInfectious tolerance via the consumption of essential amino acids and mTOR signaling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d57c9241-026c-44bf-96dc-908cafb48f2aEnglishSymplectic Elements at Oxford2009Cobbold, SAdams, EFarquhar, CNolan, KHowie, DLui, KFairchild, PMellor, ARon, DWaldmann, HInfectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs). T cells fail to proliferate in response to antigen when any 1, or more, of these EAAs are limiting, which is associated with a reduced mammalian target of rapamycin (mTOR) signaling. Inhibition of the mTOR pathway by limiting EAAs, or by specific inhibitors, induces the Treg-specific transcription factor forkhead box P3, which depends on both T cell receptor activation and synergy with TGF-beta. |
| spellingShingle | Cobbold, S Adams, E Farquhar, C Nolan, K Howie, D Lui, K Fairchild, P Mellor, A Ron, D Waldmann, H Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title | Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title_full | Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title_fullStr | Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title_full_unstemmed | Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title_short | Infectious tolerance via the consumption of essential amino acids and mTOR signaling. |
| title_sort | infectious tolerance via the consumption of essential amino acids and mtor signaling |
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