Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (...

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Bibliographic Details
Main Authors: Cobbold, S, Adams, E, Farquhar, C, Nolan, K, Howie, D, Lui, K, Fairchild, P, Mellor, A, Ron, D, Waldmann, H
Format: Journal article
Language:English
Published: 2009

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