Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (...

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Main Authors: Cobbold, S, Adams, E, Farquhar, C, Nolan, K, Howie, D, Lui, K, Fairchild, P, Mellor, A, Ron, D, Waldmann, H
格式: Journal article
语言:English
出版: 2009