CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.
CD4(+)CD25(+) regulatory T (T(R)) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombination-activating ge...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797097235706544128 |
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| author | Maloy, K Salaun, L Cahill, R Dougan, G Saunders, N Powrie, F |
| author_facet | Maloy, K Salaun, L Cahill, R Dougan, G Saunders, N Powrie, F |
| author_sort | Maloy, K |
| collection | OXFORD |
| description | CD4(+)CD25(+) regulatory T (T(R)) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombination-activating gene (RAG)(-/-) mice as a model to study the ability of CD4(+)CD25(+) T(R) cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell-independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4(+)CD25(+) T(R) cells. T cell-independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4(+)CD25(+) T(R) cells. Suppression of innate immune pathology was dependent on T cell-derived interleukin 10 and also on the production of transforming growth factor beta. Thus, CD4(+)CD25(+) T(R) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms. |
| first_indexed | 2024-03-07T04:52:41Z |
| format | Journal article |
| id | oxford-uuid:d58210df-30b4-4324-a8bb-18f95c84c484 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:52:41Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:d58210df-30b4-4324-a8bb-18f95c84c4842022-03-27T08:26:29ZCD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d58210df-30b4-4324-a8bb-18f95c84c484EnglishSymplectic Elements at Oxford2003Maloy, KSalaun, LCahill, RDougan, GSaunders, NPowrie, FCD4(+)CD25(+) regulatory T (T(R)) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombination-activating gene (RAG)(-/-) mice as a model to study the ability of CD4(+)CD25(+) T(R) cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell-independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4(+)CD25(+) T(R) cells. T cell-independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4(+)CD25(+) T(R) cells. Suppression of innate immune pathology was dependent on T cell-derived interleukin 10 and also on the production of transforming growth factor beta. Thus, CD4(+)CD25(+) T(R) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms. |
| spellingShingle | Maloy, K Salaun, L Cahill, R Dougan, G Saunders, N Powrie, F CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title | CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title_full | CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title_fullStr | CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title_full_unstemmed | CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title_short | CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. |
| title_sort | cd4 cd25 t r cells suppress innate immune pathology through cytokine dependent mechanisms |
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