Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria.
BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1(PfEMP1) is a family of variant surface antigens (VSA) that mediate the adhesion of parasite infected erythrocytes to capillary endothelial cells within host tissues. Opinion is divided over the role of PfEMP1 in the widespread endothel...
المؤلفون الرئيسيون: | Abdi, A, Fegan, G, Muthui, M, Kiragu, E, Musyoki, J, Opiyo, M, Marsh, K, Warimwe, G, Bull, P |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
BioMed Central
2014
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مواد مشابهة
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Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
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The kinetics of antibody binding to <it>Plasmodium falciparum </it>VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
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PfEMP1, polymorphism and pathogenesis.
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PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.
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