Iridium-catalyzed C4-alkylation of 2,6-di-tert-butylphenol by using hydrogen-borrowing catalysis
An iridium-catalyzed hydrogen borrowing process has been developed whereby 2,6-di-tert-butylphenol can be alkylated at the C4-position using a range of different primary alcohols (11 examples, 40–93% yield). Following this, a selection of the products obtained underwent retr...
| Principais autores: | , , |
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| Formato: | Journal article |
| Publicado em: |
Thieme
2016
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| Resumo: | An iridium-catalyzed hydrogen borrowing process has been developed whereby 2,6-di-tert-butylphenol can be alkylated at the C4-position using a range of different primary alcohols (11 examples, 40–93% yield). Following this, a selection of the products obtained underwent retroFriedel–Crafts reaction to provide para-substituted phenols which could potentially undergo further synthetic manipulation. |
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