Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed...
| Hlavní autoři: | , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
2005
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| _version_ | 1826298885712117760 |
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| author | Norbeck, O Isa, A Pöhlmann, C Broliden, K Kasprowicz, V Bowness, P Klenerman, P Tolfvenstam, T |
| author_facet | Norbeck, O Isa, A Pöhlmann, C Broliden, K Kasprowicz, V Bowness, P Klenerman, P Tolfvenstam, T |
| author_sort | Norbeck, O |
| collection | OXFORD |
| description | Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines. |
| first_indexed | 2024-03-07T04:53:36Z |
| format | Journal article |
| id | oxford-uuid:d5cf4fdd-de98-474e-a7f3-d33cf8f9ccf3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:53:36Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:d5cf4fdd-de98-474e-a7f3-d33cf8f9ccf32022-03-27T08:28:47ZSustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d5cf4fdd-de98-474e-a7f3-d33cf8f9ccf3EnglishSymplectic Elements at Oxford2005Norbeck, OIsa, APöhlmann, CBroliden, KKasprowicz, VBowness, PKlenerman, PTolfvenstam, TMurine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines. |
| spellingShingle | Norbeck, O Isa, A Pöhlmann, C Broliden, K Kasprowicz, V Bowness, P Klenerman, P Tolfvenstam, T Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title | Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title_full | Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title_fullStr | Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title_full_unstemmed | Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title_short | Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. |
| title_sort | sustained cd8 t cell responses induced after acute parvovirus b19 infection in humans |
| work_keys_str_mv | AT norbecko sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT isaa sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT pohlmannc sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT brolidenk sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT kasprowiczv sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT bownessp sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT klenermanp sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans AT tolfvenstamt sustainedcd8tcellresponsesinducedafteracuteparvovirusb19infectioninhumans |