Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Rap1 is a component of the shelterin complex at mammalian telomeres, but its in vivo role in telomere biology has remained largely unknown to date. Here we show that Rap1 deficiency is dispensable for telomere capping but leads to increased telomere recombination and fragility. We generated cells an...
| Main Authors: | , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2010
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