An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

Ewing's sarcoma is a pediatric cancer of the bone that is characterized by the expression of the chimeric transcription factor EWS-FLI1 that confers a highly malignant phenotype and results from the chromosomal translocation t(11;22)(q24;q12). Poor overall survival and pronounced long-term side...

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Bibliographic Details
Main Authors:	Winter, G, Rix, U, Lissat, A, Stukalov, A, Müllner, M, Bennett, K, Colinge, J, Nijman, S, Kubicek, S, Kovar, H, Kontny, U, Superti-Furga, G
Format:	Journal article
Language:	English
Published:	2011

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