The heritability of multi-modal connectivity in human brain activity
Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determini...
| Main Authors: | , , , , , , , |
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| פורמט: | Journal article |
| יצא לאור: |
eLife Sciences Publications
2017
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| _version_ | 1826298927358410752 |
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| author | Colclough, G Smith, S Nichols, T Winkler, A Sotiropoulos, S Glasser, M Van Essen, D Woolrich, M |
| author_facet | Colclough, G Smith, S Nichols, T Winkler, A Sotiropoulos, S Glasser, M Van Essen, D Woolrich, M |
| author_sort | Colclough, G |
| collection | OXFORD |
| description | Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity between 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, play a dominant role in determining the coupling of neuronal activity. |
| first_indexed | 2024-03-07T04:54:11Z |
| format | Journal article |
| id | oxford-uuid:d608cb69-a2d3-4163-a8a7-df6086932475 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:54:11Z |
| publishDate | 2017 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:d608cb69-a2d3-4163-a8a7-df60869324752022-03-27T08:30:21ZThe heritability of multi-modal connectivity in human brain activityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d608cb69-a2d3-4163-a8a7-df6086932475Symplectic Elements at OxfordeLife Sciences Publications2017Colclough, GSmith, SNichols, TWinkler, ASotiropoulos, SGlasser, MVan Essen, DWoolrich, MPatterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity between 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, play a dominant role in determining the coupling of neuronal activity. |
| spellingShingle | Colclough, G Smith, S Nichols, T Winkler, A Sotiropoulos, S Glasser, M Van Essen, D Woolrich, M The heritability of multi-modal connectivity in human brain activity |
| title | The heritability of multi-modal connectivity in human brain activity |
| title_full | The heritability of multi-modal connectivity in human brain activity |
| title_fullStr | The heritability of multi-modal connectivity in human brain activity |
| title_full_unstemmed | The heritability of multi-modal connectivity in human brain activity |
| title_short | The heritability of multi-modal connectivity in human brain activity |
| title_sort | heritability of multi modal connectivity in human brain activity |
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