Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

<p>Tripartite motif-containing protein 24 (TRIM24) is an epigenetic transcriptional regulator involved in reading histone 3 (H3) methylated (KMe<sub><em>x</em></sub>) and acetylated (KAc) lysine post-translational modifications (PTMs) through an adjacent plant homeodoma...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Platt, MA
Awduron Eraill:	Conway, S
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2024
Pynciau:	Chemical biology Organic synthesis Epigenetics

Eitemau Tebyg

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
gan: Hay, D
Cyhoeddwyd: (2014)

Developing inhibitors of bromodomain-histone interactions
gan: Hewings, D
Cyhoeddwyd: (2014)

Computational studies of ligand binding to TRIM PHD-bromodomains
gan: Lee, B
Cyhoeddwyd: (2023)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
gan: Carter, JL
Cyhoeddwyd: (2023)

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
gan: Bunce, HAP
Cyhoeddwyd: (2021)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
gan: McArdle, DJB
Cyhoeddwyd: (2023)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
gan: Riley M. Horvath, et al.
Cyhoeddwyd: (2023-01-01)

Development of small molecule inhibitors of the bromodomain-histone interaction
gan: Rooney, TPC
Cyhoeddwyd: (2014)

Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
gan: Hancock, R
Cyhoeddwyd: (2016)

Design, synthesis and application of novel light-activated molecular probes
gan: Stanton-Humphreys, M, et al.
Cyhoeddwyd: (2010)

Histone lysine and DNA methylation: dynamic marks in the chromatin
gan: Belle, R
Cyhoeddwyd: (2019)

A potent and selective inhibitor of a histone demethylase
gan: England, K
Cyhoeddwyd: (2016)

Development of ligands for the TRIM33 bromodomain
gan: See, L
Cyhoeddwyd: (2018)

Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains
gan: Sekirnik, AR, et al.
Cyhoeddwyd: (2022)

Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation
gan: Meier, JC, et al.
Cyhoeddwyd: (2017)

Asymmetric conjugate addition reactions
gan: Bentley, S, et al.
Cyhoeddwyd: (2011)

Structural and functional studies on human PHD finger protein 2
gan: Xian, D, et al.
Cyhoeddwyd: (2014)

Small molecule inhibitors and substrate analyses of protein arginine methyltransferases
gan: Varney, A
Cyhoeddwyd: (2015)

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains
gan: Boyd, AM
Cyhoeddwyd: (2024)

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
gan: Veronica Garcia-Carpizo, et al.
Cyhoeddwyd: (2018-06-01)

Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells
gan: Liad Margalit, et al.
Cyhoeddwyd: (2020-09-01)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
gan: Saliba, R, et al.
Cyhoeddwyd: (2014)

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
gan: Wendy Mao, et al.
Cyhoeddwyd: (2019-10-01)

Biological applications of chemically modified recombinant histones
gan: Josephson, B
Cyhoeddwyd: (2022)

New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging
gan: Alfredo Martínez-Gutiérrez, et al.
Cyhoeddwyd: (2024-10-01)

Bromodomain inhibitors and cancer therapy: From structures to applications
gan: Montserrat Pérez-Salvia, et al.
Cyhoeddwyd: (2017-05-01)

1D AND 2D NMR STUDIES OF BENZYL O-V ANILLIN
gan: AI-DOUH, Mohammed Hadi
Cyhoeddwyd: (2008)

Development of affinity and fluorescent probes to elucidate the mechanism of small molecule modulators of neurogenesis
gan: Sim, R
Cyhoeddwyd: (2021)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
gan: Ye, Y
Cyhoeddwyd: (2013)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
gan: Kenneth K. W. To, et al.
Cyhoeddwyd: (2023-03-01)

Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization
gan: Sae Suzuki, et al.
Cyhoeddwyd: (2023-04-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
gan: Jennings, L, et al.
Cyhoeddwyd: (2018)

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
gan: Bowen Wang, et al.
Cyhoeddwyd: (2015-11-01)

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
gan: Wolfreys, F
Cyhoeddwyd: (2017)

A multi-step solvent-free mechanochemical route to indium(III) complexes
gan: Wang, Jingyi, et al.
Cyhoeddwyd: (2016)

Development of ligands to target bromodomain-histone interactions
gan: Jennings, L
Cyhoeddwyd: (2015)

Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
gan: Goodfellow, J, et al.
Cyhoeddwyd: (2011)

Modification and application of glycosidases to create homogeneous glycoconjugates
gan: Yamamoto, K, et al.
Cyhoeddwyd: (2013)

Functional networks of the human bromodomain-containing proteins
gan: Cong Gao, et al.
Cyhoeddwyd: (2022-08-01)

Identification of Novel Bromodomain-Containing Protein 4 (BRD4) Binders through 3D Pharmacophore-Based Repositioning Screening Campaign
gan: Ester Colarusso, et al.
Cyhoeddwyd: (2024-08-01)