Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

<p>Tripartite motif-containing protein 24 (TRIM24) is an epigenetic transcriptional regulator involved in reading histone 3 (H3) methylated (KMe<sub><em>x</em></sub>) and acetylated (KAc) lysine post-translational modifications (PTMs) through an adjacent plant homeodoma...

Bibliografiset tiedot
Päätekijä:	Platt, MA
Muut tekijät:	Conway, S
Aineistotyyppi:	Opinnäyte
Kieli:	English
Julkaistu:	2024
Aiheet:	Chemical biology Organic synthesis Epigenetics

Samankaltaisia teoksia

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
Tekijä: Hay, D
Julkaistu: (2014)

Developing inhibitors of bromodomain-histone interactions
Tekijä: Hewings, D
Julkaistu: (2014)

Computational studies of ligand binding to TRIM PHD-bromodomains
Tekijä: Lee, B
Julkaistu: (2023)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
Tekijä: Carter, JL
Julkaistu: (2023)

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
Tekijä: Bunce, HAP
Julkaistu: (2021)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
Tekijä: McArdle, DJB
Julkaistu: (2023)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
Tekijä: Riley M. Horvath, et al.
Julkaistu: (2023-01-01)

Development of small molecule inhibitors of the bromodomain-histone interaction
Tekijä: Rooney, TPC
Julkaistu: (2014)

Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
Tekijä: Hancock, R
Julkaistu: (2016)

Design, synthesis and application of novel light-activated molecular probes
Tekijä: Stanton-Humphreys, M, et al.
Julkaistu: (2010)

Histone lysine and DNA methylation: dynamic marks in the chromatin
Tekijä: Belle, R
Julkaistu: (2019)

A potent and selective inhibitor of a histone demethylase
Tekijä: England, K
Julkaistu: (2016)

Development of ligands for the TRIM33 bromodomain
Tekijä: See, L
Julkaistu: (2018)

Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains
Tekijä: Sekirnik, AR, et al.
Julkaistu: (2022)

Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation
Tekijä: Meier, JC, et al.
Julkaistu: (2017)

Asymmetric conjugate addition reactions
Tekijä: Bentley, S, et al.
Julkaistu: (2011)

Structural and functional studies on human PHD finger protein 2
Tekijä: Xian, D, et al.
Julkaistu: (2014)

Small molecule inhibitors and substrate analyses of protein arginine methyltransferases
Tekijä: Varney, A
Julkaistu: (2015)

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains
Tekijä: Boyd, AM
Julkaistu: (2024)

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
Tekijä: Veronica Garcia-Carpizo, et al.
Julkaistu: (2018-06-01)

Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells
Tekijä: Liad Margalit, et al.
Julkaistu: (2020-09-01)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
Tekijä: Saliba, R, et al.
Julkaistu: (2014)

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
Tekijä: Wendy Mao, et al.
Julkaistu: (2019-10-01)

Biological applications of chemically modified recombinant histones
Tekijä: Josephson, B
Julkaistu: (2022)

New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging
Tekijä: Alfredo Martínez-Gutiérrez, et al.
Julkaistu: (2024-10-01)

Bromodomain inhibitors and cancer therapy: From structures to applications
Tekijä: Montserrat Pérez-Salvia, et al.
Julkaistu: (2017-05-01)

1D AND 2D NMR STUDIES OF BENZYL O-V ANILLIN
Tekijä: AI-DOUH, Mohammed Hadi
Julkaistu: (2008)

Development of affinity and fluorescent probes to elucidate the mechanism of small molecule modulators of neurogenesis
Tekijä: Sim, R
Julkaistu: (2021)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
Tekijä: Ye, Y
Julkaistu: (2013)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Tekijä: Kenneth K. W. To, et al.
Julkaistu: (2023-03-01)

Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization
Tekijä: Sae Suzuki, et al.
Julkaistu: (2023-04-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Tekijä: Jennings, L, et al.
Julkaistu: (2018)

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
Tekijä: Bowen Wang, et al.
Julkaistu: (2015-11-01)

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
Tekijä: Wolfreys, F
Julkaistu: (2017)

A multi-step solvent-free mechanochemical route to indium(III) complexes
Tekijä: Wang, Jingyi, et al.
Julkaistu: (2016)

Development of ligands to target bromodomain-histone interactions
Tekijä: Jennings, L
Julkaistu: (2015)

Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
Tekijä: Goodfellow, J, et al.
Julkaistu: (2011)

Modification and application of glycosidases to create homogeneous glycoconjugates
Tekijä: Yamamoto, K, et al.
Julkaistu: (2013)

Functional networks of the human bromodomain-containing proteins
Tekijä: Cong Gao, et al.
Julkaistu: (2022-08-01)

Identification of Novel Bromodomain-Containing Protein 4 (BRD4) Binders through 3D Pharmacophore-Based Repositioning Screening Campaign
Tekijä: Ester Colarusso, et al.
Julkaistu: (2024-08-01)