Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain

<p>Tripartite motif-containing protein 24 (TRIM24) is an epigenetic transcriptional regulator involved in reading histone 3 (H3) methylated (KMe<sub><em>x</em></sub>) and acetylated (KAc) lysine post-translational modifications (PTMs) through an adjacent plant homeodoma...

Bibliografski detalji
Glavni autor:	Platt, MA
Daljnji autori:	Conway, S
Format:	Disertacija
Jezik:	English
Izdano:	2024
Teme:	Chemical biology Organic synthesis Epigenetics

Slični predmeti

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
od: Hay, D
Izdano: (2014)

Developing inhibitors of bromodomain-histone interactions
od: Hewings, D
Izdano: (2014)

Computational studies of ligand binding to TRIM PHD-bromodomains
od: Lee, B
Izdano: (2023)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
od: Carter, JL
Izdano: (2023)

Development of small-molecule, peptide-mimetic, activating ligands of the potassium efflux (Kef) system
od: Bunce, HAP
Izdano: (2021)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
od: McArdle, DJB
Izdano: (2023)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
od: Riley M. Horvath, i dr.
Izdano: (2023-01-01)

Development of small molecule inhibitors of the bromodomain-histone interaction
od: Rooney, TPC
Izdano: (2014)

Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
od: Hancock, R
Izdano: (2016)

Design, synthesis and application of novel light-activated molecular probes
od: Stanton-Humphreys, M, i dr.
Izdano: (2010)

Histone lysine and DNA methylation: dynamic marks in the chromatin
od: Belle, R
Izdano: (2019)

A potent and selective inhibitor of a histone demethylase
od: England, K
Izdano: (2016)

Development of ligands for the TRIM33 bromodomain
od: See, L
Izdano: (2018)

Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains
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Izdano: (2022)

Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation
od: Meier, JC, i dr.
Izdano: (2017)

Asymmetric conjugate addition reactions
od: Bentley, S, i dr.
Izdano: (2011)

Structural and functional studies on human PHD finger protein 2
od: Xian, D, i dr.
Izdano: (2014)

Small molecule inhibitors and substrate analyses of protein arginine methyltransferases
od: Varney, A
Izdano: (2015)

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains
od: Boyd, AM
Izdano: (2024)

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
od: Veronica Garcia-Carpizo, i dr.
Izdano: (2018-06-01)

Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells
od: Liad Margalit, i dr.
Izdano: (2020-09-01)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
od: Saliba, R, i dr.
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Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
od: Wendy Mao, i dr.
Izdano: (2019-10-01)

Biological applications of chemically modified recombinant histones
od: Josephson, B
Izdano: (2022)

New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging
od: Alfredo Martínez-Gutiérrez, i dr.
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1D AND 2D NMR STUDIES OF BENZYL O-V ANILLIN
od: AI-DOUH, Mohammed Hadi
Izdano: (2008)

Bromodomain inhibitors and cancer therapy: From structures to applications
od: Montserrat Pérez-Salvia, i dr.
Izdano: (2017-05-01)

Development of affinity and fluorescent probes to elucidate the mechanism of small molecule modulators of neurogenesis
od: Sim, R
Izdano: (2021)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
od: Ye, Y
Izdano: (2013)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
od: Kenneth K. W. To, i dr.
Izdano: (2023-03-01)

Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization
od: Sae Suzuki, i dr.
Izdano: (2023-04-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
od: Jennings, L, i dr.
Izdano: (2018)

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
od: Wolfreys, F
Izdano: (2017)

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
od: Bowen Wang, i dr.
Izdano: (2015-11-01)

A multi-step solvent-free mechanochemical route to indium(III) complexes
od: Wang, Jingyi, i dr.
Izdano: (2016)

Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
od: Goodfellow, J, i dr.
Izdano: (2011)

Development of ligands to target bromodomain-histone interactions
od: Jennings, L
Izdano: (2015)

Modification and application of glycosidases to create homogeneous glycoconjugates
od: Yamamoto, K, i dr.
Izdano: (2013)

Functional networks of the human bromodomain-containing proteins
od: Cong Gao, i dr.
Izdano: (2022-08-01)

Identification of Novel Bromodomain-Containing Protein 4 (BRD4) Binders through 3D Pharmacophore-Based Repositioning Screening Campaign
od: Ester Colarusso, i dr.
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