Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.

Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell. PDH activity is under the control of pyruvate dehydrogenase kinases (PDKs). Under hypoxic conditions, conversion of pyruvate...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Koukourakis, M, Giatromanolaki, A, Sivridis, E, Gatter, K, Harris, A
Natura:	Journal article
Lingua:	English
Pubblicazione:	2005

Documenti analoghi

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
di: Michael I. Koukourakis, et al.
Pubblicazione: (2005-01-01)

Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
di: Priestman, D, et al.
Pubblicazione: (1997)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
di: Ji Yun Jeong, et al.
Pubblicazione: (2012-10-01)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
di: In-Kyu Lee
Pubblicazione: (2014-06-01)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
di: Nam Ho Jeoung
Pubblicazione: (2015-06-01)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
di: Sungmi Park, et al.
Pubblicazione: (2018-08-01)

Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.
di: Koukourakis, M, et al.
Pubblicazione: (2003)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
di: Mariana Galvão Ferrarini, et al.
Pubblicazione: (2021-02-01)

Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.
di: Giatromanolaki, A, et al.
Pubblicazione: (2008)

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology
di: Gopinath eSutendra, et al.
Pubblicazione: (2013-03-01)

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.
di: Koukourakis, M, et al.
Pubblicazione: (2003)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
di: Kazuhisa Honda, et al.
Pubblicazione: (2017-10-01)

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
di: Chenyu Li, et al.
Pubblicazione: (2023-12-01)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
di: Jaechan Leem, et al.
Pubblicazione: (2016-03-01)

Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
di: Rongya Tao, et al.
Pubblicazione: (2013-01-01)

Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group.
di: Koukourakis, M, et al.
Pubblicazione: (2006)

Fatty acids and the regulation of pyruvate dehydrogenase interconversion
di: Stewart, M, et al.
Pubblicazione: (1997)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
di: Forteza, MJ, et al.
Pubblicazione: (2023)

Pyruvic Acid Production from Sucrose by <i>Escherichia coli</i> Pyruvate Dehydrogenase Variants
di: W. Chris Moxley, et al.
Pubblicazione: (2023-05-01)

Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy
di: Lewis, A, et al.
Pubblicazione: (2016)

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
di: Manasa K. Nayak, et al.
Pubblicazione: (2018-08-01)

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
di: Yu-Hsuan Kuo, et al.
Pubblicazione: (2021-09-01)

The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism
di: Laure Nicolas Annick Ries, et al.
Pubblicazione: (2018-07-01)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
di: Jirair K. Bedoyan, et al.
Pubblicazione: (2019-07-01)

Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy
di: Saleha Anwar, et al.
Pubblicazione: (2020-05-01)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
di: Byong-Keol Min, et al.
Pubblicazione: (2019-05-01)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
di: Alexa Thibodeau, et al.
Pubblicazione: (2016-01-01)

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer
di: Caroline E. Nunes-Xavier, et al.
Pubblicazione: (2022-05-01)

Escherichia coli aceE variants coding pyruvate dehydrogenase improve the generation of pyruvate‐derived acetoin
di: W. Chris Moxley, et al.
Pubblicazione: (2023-03-01)

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal InflammationSummary
di: Hoyul Lee, et al.
Pubblicazione: (2023-01-01)

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
di: Abu Jubayer Hossain, et al.
Pubblicazione: (2022-05-01)

The Role of the Pyruvate Dehydrogenase Complex in the Development of Ischemic-Reperfusion Syndrome
di: K. A. Popov, et al.
Pubblicazione: (2022-08-01)

Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
di: Ibotombi Singh Sinam, et al.
Pubblicazione: (2022-12-01)

Pyruvate Dehydrogenase Kinase 4: A Key Mediator for Metabolic Regulation of Liver Regeneration
di: James Burdick, et al.
Pubblicazione: (2020-04-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
di: Zahra Rezaei, et al.
Pubblicazione: (2017-03-01)

Modulation of Muscle Fiber Compositions in Response to Hypoxia via Pyruvate Dehydrogenase Kinase-1
di: Daniel Nguyen, et al.
Pubblicazione: (2016-12-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
di: Zahra Rezaei, et al.
Pubblicazione: (2017-03-01)

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
di: Md Habibur Rahman, et al.
Pubblicazione: (2020-11-01)

Effects of zinc oxide nanoparticles on pyruvate dehydrogenase and lactate dehydrogenase expressions and apoptotic index in breast cancer cells
di: Cem ÖZİÇ, et al.
Pubblicazione: (2024-06-01)

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase
di: Priestman, D, et al.
Pubblicazione: (1994)