Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2015
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| _version_ | 1797097371865186304 |
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| author | Brenna, J Akomo, P Bahwere, P Berkley, J Calder, P Jones, K Liu, L Manary, M Trehan, I Briend, A |
| author_facet | Brenna, J Akomo, P Bahwere, P Berkley, J Calder, P Jones, K Liu, L Manary, M Trehan, I Briend, A |
| author_sort | Brenna, J |
| collection | OXFORD |
| description | Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands. |
| first_indexed | 2024-03-07T04:54:32Z |
| format | Journal article |
| id | oxford-uuid:d624914d-ac85-4a0a-a6f9-3eb317be3383 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:54:32Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:d624914d-ac85-4a0a-a6f9-3eb317be33832022-03-27T08:31:11ZBalancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d624914d-ac85-4a0a-a6f9-3eb317be3383EnglishSymplectic Elements at OxfordBioMed Central2015Brenna, JAkomo, PBahwere, PBerkley, JCalder, PJones, KLiu, LManary, MTrehan, IBriend, AReady-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands. |
| spellingShingle | Brenna, J Akomo, P Bahwere, P Berkley, J Calder, P Jones, K Liu, L Manary, M Trehan, I Briend, A Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title_full | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title_fullStr | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title_full_unstemmed | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title_short | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
| title_sort | balancing omega 6 and omega 3 fatty acids in ready to use therapeutic foods rutf |
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