Human platelet antigen 1a epitopes are dependent on the cation-regulated conformation of integrin α(IIb)β(3) (GPIIb/IIIa).
BACKGROUND: The HPA-1a (Leu(33)) polymorphism of platelet integrin αIIbβ3 is the target of alloantibodies in 70-80% cases of neonatal alloimmune thrombocytopenia (NAIT) in Caucasians and reliable detection of these antibodies is essential for appropriate clinical management. However, the ability to...
| Main Authors: | , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2012
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