Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging.
Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a "hit region" of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can ma...
| Glavni autori: | , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2012
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