Benzosultam synthesis exploiting sequential palladium-catalysed intermolecular aminosulfonylation and intramolecular sulfamidation
We report a route to benzosultams that exploits the palladium-catalysed aminsulfonylation of alkenyl iodides as the initial step. An (Z)-configured alkenyl iodide substrate is combined with DABSO, a N,N-dialkylhydrazine nucleophile and a palladium(0) catalyst to achieve aminsulfonylation. A second p...
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| Fformat: | Journal article |
| Iaith: | English |
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Elsevier
2021
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