Analysis of IL10 haplotypic associations with severe malaria.

We investigated the association between severe malaria and genetic variation of IL10 in Gambian children, as several lines of evidence indicate that IL10 is protective against severe malaria and that IL10 production is genetically determined. We began by identifying five informative SNPs in the Gamb...

Full description

Bibliographic Details
Main Authors: Wilson, J, Rockett, K, Jallow, M, Pinder, M, Sisay-Joof, F, Newport, M, Newton, J, Kwiatkowski, D
Format: Journal article
Language:English
Published: 2005
_version_ 1797097406580391936
author Wilson, J
Rockett, K
Jallow, M
Pinder, M
Sisay-Joof, F
Newport, M
Newton, J
Kwiatkowski, D
author_facet Wilson, J
Rockett, K
Jallow, M
Pinder, M
Sisay-Joof, F
Newport, M
Newton, J
Kwiatkowski, D
author_sort Wilson, J
collection OXFORD
description We investigated the association between severe malaria and genetic variation of IL10 in Gambian children, as several lines of evidence indicate that IL10 is protective against severe malaria and that IL10 production is genetically determined. We began by identifying five informative SNPs in the Gambian population that were genotyped in a combined case-control and intrafamilial study including 654 cases of severe malaria, 579 sets of parents and 459 ethnically matched controls. No significant associations were identified with individual SNPs. One haplotype of frequency 0.11 was strongly associated with protection against severe malaria in the case-control analysis (odds ratio 0.52, P=0.00002), but the transmission disequilibrium test in families showed no significant effect. These findings raise the question of whether IL10 associations with severe malaria might be confounded by foetal survival rates or other sources of transmission bias.
first_indexed 2024-03-07T04:55:02Z
format Journal article
id oxford-uuid:d64d3669-12de-4520-a329-291a9f7ad87e
institution University of Oxford
language English
last_indexed 2024-03-07T04:55:02Z
publishDate 2005
record_format dspace
spelling oxford-uuid:d64d3669-12de-4520-a329-291a9f7ad87e2022-03-27T08:32:31ZAnalysis of IL10 haplotypic associations with severe malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d64d3669-12de-4520-a329-291a9f7ad87eEnglishSymplectic Elements at Oxford2005Wilson, JRockett, KJallow, MPinder, MSisay-Joof, FNewport, MNewton, JKwiatkowski, DWe investigated the association between severe malaria and genetic variation of IL10 in Gambian children, as several lines of evidence indicate that IL10 is protective against severe malaria and that IL10 production is genetically determined. We began by identifying five informative SNPs in the Gambian population that were genotyped in a combined case-control and intrafamilial study including 654 cases of severe malaria, 579 sets of parents and 459 ethnically matched controls. No significant associations were identified with individual SNPs. One haplotype of frequency 0.11 was strongly associated with protection against severe malaria in the case-control analysis (odds ratio 0.52, P=0.00002), but the transmission disequilibrium test in families showed no significant effect. These findings raise the question of whether IL10 associations with severe malaria might be confounded by foetal survival rates or other sources of transmission bias.
spellingShingle Wilson, J
Rockett, K
Jallow, M
Pinder, M
Sisay-Joof, F
Newport, M
Newton, J
Kwiatkowski, D
Analysis of IL10 haplotypic associations with severe malaria.
title Analysis of IL10 haplotypic associations with severe malaria.
title_full Analysis of IL10 haplotypic associations with severe malaria.
title_fullStr Analysis of IL10 haplotypic associations with severe malaria.
title_full_unstemmed Analysis of IL10 haplotypic associations with severe malaria.
title_short Analysis of IL10 haplotypic associations with severe malaria.
title_sort analysis of il10 haplotypic associations with severe malaria
work_keys_str_mv AT wilsonj analysisofil10haplotypicassociationswithseveremalaria
AT rockettk analysisofil10haplotypicassociationswithseveremalaria
AT jallowm analysisofil10haplotypicassociationswithseveremalaria
AT pinderm analysisofil10haplotypicassociationswithseveremalaria
AT sisayjooff analysisofil10haplotypicassociationswithseveremalaria
AT newportm analysisofil10haplotypicassociationswithseveremalaria
AT newtonj analysisofil10haplotypicassociationswithseveremalaria
AT kwiatkowskid analysisofil10haplotypicassociationswithseveremalaria