What is the minimal length of calcium pentosan polysulfate that is able to block aggrecan breakdown in cartilage?

Eitemau Tebyg

• Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2009)
• Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2008)
• Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2010)
• Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2012)
• Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2012)