Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children.
BACKGROUND: In the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The course of HIV-1 infection in these children is variable, and understudied. METHODOLOGY/PRINCIPAL FINDINGS: We determined whether qual...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797097422086733824 |
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| author | Sharp, E Willberg, C Kuebler, P Abadi, J Fennelly, G Dobroszycki, J Wiznia, A Rosenberg, MG Nixon, D |
| author_facet | Sharp, E Willberg, C Kuebler, P Abadi, J Fennelly, G Dobroszycki, J Wiznia, A Rosenberg, MG Nixon, D |
| author_sort | Sharp, E |
| collection | OXFORD |
| description | BACKGROUND: In the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The course of HIV-1 infection in these children is variable, and understudied. METHODOLOGY/PRINCIPAL FINDINGS: We determined whether qualitative differences in immune cell subsets could explain a slower disease course in long term survivors with no evidence of immune suppression (LTS-NS; CD4%≥25%) compared to those with severe immune suppression (LTS-SS; CD4%≤15%). Subjects in the LTS-NS group had significantly higher frequencies of naïve (CCR7+CD45RA+) and central memory (CCR7+CD45RA-) CD4+ T cells compared to LTS-SS subjects (p = 0.0005 and <0.0001, respectively). Subjects in the rapid progressing group had significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells compared to slow progressing subjects (p<0.0001). CONCLUSIONS/SIGNIFICANCE: Rapid disease progression in vertical infection is associated with significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells. |
| first_indexed | 2024-03-07T04:55:16Z |
| format | Journal article |
| id | oxford-uuid:d6621a43-2bec-4083-a2a3-624524ee0f0f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:55:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:d6621a43-2bec-4083-a2a3-624524ee0f0f2022-03-27T08:33:05ZAssociation of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6621a43-2bec-4083-a2a3-624524ee0f0fEnglishSymplectic Elements at Oxford2012Sharp, EWillberg, CKuebler, PAbadi, JFennelly, GDobroszycki, JWiznia, ARosenberg, MGNixon, D BACKGROUND: In the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The course of HIV-1 infection in these children is variable, and understudied. METHODOLOGY/PRINCIPAL FINDINGS: We determined whether qualitative differences in immune cell subsets could explain a slower disease course in long term survivors with no evidence of immune suppression (LTS-NS; CD4%≥25%) compared to those with severe immune suppression (LTS-SS; CD4%≤15%). Subjects in the LTS-NS group had significantly higher frequencies of naïve (CCR7+CD45RA+) and central memory (CCR7+CD45RA-) CD4+ T cells compared to LTS-SS subjects (p = 0.0005 and <0.0001, respectively). Subjects in the rapid progressing group had significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells compared to slow progressing subjects (p<0.0001). CONCLUSIONS/SIGNIFICANCE: Rapid disease progression in vertical infection is associated with significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells. |
| spellingShingle | Sharp, E Willberg, C Kuebler, P Abadi, J Fennelly, G Dobroszycki, J Wiznia, A Rosenberg, MG Nixon, D Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title | Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title_full | Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title_fullStr | Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title_full_unstemmed | Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title_short | Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. |
| title_sort | association of differentiation state of cd4 t cells and disease progression in hiv 1 perinatally infected children |
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