G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

AIMS/HYPOTHESIS: Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Ferdaoussi, M, Bergeron, V, Zarrouki, B, Kolic, J, Cantley, J, Fielitz, J, Olson, E, Prentki, M, Biden, T, MacDonald, P, Poitout, V
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2012