A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium.
Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Journal article |
Lenguaje: | English |
Publicado: |
1998
|
_version_ | 1826299009943207936 |
---|---|
author | Bailey, A Hervas, A Matthews, N Palferman, S Wallace, S Aubin, A Michelotti, J Wainhouse, C Papanikolaou, K Rutter, M Maestrini, E Marlow, A Weeks, D Lamb, J Francks, C Kearsley, G Scudder, P Monaco, A Baird, G Cox, A Cockerill, H Le Couteur, A Berney, T Cooper, H Kelly, T |
author_facet | Bailey, A Hervas, A Matthews, N Palferman, S Wallace, S Aubin, A Michelotti, J Wainhouse, C Papanikolaou, K Rutter, M Maestrini, E Marlow, A Weeks, D Lamb, J Francks, C Kearsley, G Scudder, P Monaco, A Baird, G Cox, A Cockerill, H Le Couteur, A Berney, T Cooper, H Kelly, T |
author_sort | Bailey, A |
collection | OXFORD |
description | Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study. |
first_indexed | 2024-03-07T04:55:24Z |
format | Journal article |
id | oxford-uuid:d66f0c7c-0edc-4822-a65b-148aa6136af7 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T04:55:24Z |
publishDate | 1998 |
record_format | dspace |
spelling | oxford-uuid:d66f0c7c-0edc-4822-a65b-148aa6136af72022-03-27T08:33:31ZA full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d66f0c7c-0edc-4822-a65b-148aa6136af7EnglishSymplectic Elements at Oxford1998Bailey, AHervas, AMatthews, NPalferman, SWallace, SAubin, AMichelotti, JWainhouse, CPapanikolaou, KRutter, MMaestrini, EMarlow, AWeeks, DLamb, JFrancks, CKearsley, GScudder, PMonaco, ABaird, GCox, ACockerill, HLe Couteur, ABerney, TCooper, HKelly, TAutism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study. |
spellingShingle | Bailey, A Hervas, A Matthews, N Palferman, S Wallace, S Aubin, A Michelotti, J Wainhouse, C Papanikolaou, K Rutter, M Maestrini, E Marlow, A Weeks, D Lamb, J Francks, C Kearsley, G Scudder, P Monaco, A Baird, G Cox, A Cockerill, H Le Couteur, A Berney, T Cooper, H Kelly, T A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title | A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title_full | A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title_fullStr | A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title_full_unstemmed | A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title_short | A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |
title_sort | full genome screen for autism with evidence for linkage to a region on chromosome 7q international molecular genetic study of autism consortium |
work_keys_str_mv | AT baileya afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT hervasa afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT matthewsn afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT palfermans afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT wallaces afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT aubina afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT michelottij afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT wainhousec afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT papanikolaouk afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT rutterm afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT maestrinie afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT marlowa afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT weeksd afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT lambj afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT francksc afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT kearsleyg afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT scudderp afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT monacoa afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT bairdg afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT coxa afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT cockerillh afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT lecouteura afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT berneyt afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT cooperh afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT kellyt afullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT baileya fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT hervasa fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT matthewsn fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT palfermans fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT wallaces fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT aubina fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT michelottij fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT wainhousec fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT papanikolaouk fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT rutterm fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT maestrinie fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT marlowa fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT weeksd fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT lambj fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT francksc fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT kearsleyg fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT scudderp fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT monacoa fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT bairdg fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT coxa fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT cockerillh fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT lecouteura fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT berneyt fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT cooperh fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium AT kellyt fullgenomescreenforautismwithevidenceforlinkagetoaregiononchromosome7qinternationalmoleculargeneticstudyofautismconsortium |