Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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American Association for the Advancement of Science
2016
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| _version_ | 1797097434835320832 |
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| author | Moody, M Pedroza-Pacheco, I Vandergrift, N Chui, C Lloyd, K Parks, R Ogbe, A Cohen, M Liao, H Gao, F McMichael, A Montefiori, D Verkoczy, L Kelsoe, G Huang, J Shea, P Connors, M Borrow, P Haynes, B |
| author_facet | Moody, M Pedroza-Pacheco, I Vandergrift, N Chui, C Lloyd, K Parks, R Ogbe, A Cohen, M Liao, H Gao, F McMichael, A Montefiori, D Verkoczy, L Kelsoe, G Huang, J Shea, P Connors, M Borrow, P Haynes, B |
| author_sort | Moody, M |
| collection | OXFORD |
| description | Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death–1 expression compared with HIV-1–infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1–infected individuals. |
| first_indexed | 2024-03-07T04:55:27Z |
| format | Journal article |
| id | oxford-uuid:d6749a0f-e82e-4ea5-81a3-c37d91f714d4 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:55:27Z |
| publishDate | 2016 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:d6749a0f-e82e-4ea5-81a3-c37d91f714d42022-03-27T08:33:38ZImmune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6749a0f-e82e-4ea5-81a3-c37d91f714d4Symplectic Elements at OxfordAmerican Association for the Advancement of Science2016Moody, MPedroza-Pacheco, IVandergrift, NChui, CLloyd, KParks, ROgbe, ACohen, MLiao, HGao, FMcMichael, AMontefiori, DVerkoczy, LKelsoe, GHuang, JShea, PConnors, MBorrow, PHaynes, BInduction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death–1 expression compared with HIV-1–infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1–infected individuals. |
| spellingShingle | Moody, M Pedroza-Pacheco, I Vandergrift, N Chui, C Lloyd, K Parks, R Ogbe, A Cohen, M Liao, H Gao, F McMichael, A Montefiori, D Verkoczy, L Kelsoe, G Huang, J Shea, P Connors, M Borrow, P Haynes, B Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title | Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title_full | Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title_fullStr | Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title_full_unstemmed | Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title_short | Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies |
| title_sort | immune perturbations in hiv 1 infected individuals who make broadly neutralizing antibodies |
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