Variation on a theme: mapping microglial heterogeneity
Young et al. examine the complexity of primary human microglia, and identify previously unknown cell states. Using expression quantitative trait locus (eQTL) mapping techniques, they identify 129 genes whose expression in microglia is linked to disease, and show that induced pluripotent stem cell (i...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2021
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| _version_ | 1797107759207940096 |
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| author | Washer, SJ Bassett, AR Cowley, SA |
| author_facet | Washer, SJ Bassett, AR Cowley, SA |
| author_sort | Washer, SJ |
| collection | OXFORD |
| description | Young et al. examine the complexity of primary human microglia, and identify previously unknown cell states. Using expression quantitative trait locus (eQTL) mapping techniques, they identify 129 genes whose expression in microglia is linked to disease, and show that induced pluripotent stem cell (iPSC) models can be used for functional validation of common genetic mutations in microglia-associated diseases.
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| first_indexed | 2024-03-07T07:20:26Z |
| format | Journal article |
| id | oxford-uuid:d677138c-fd2e-4978-8390-263033da5570 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:20:26Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:d677138c-fd2e-4978-8390-263033da55702022-09-23T09:10:36ZVariation on a theme: mapping microglial heterogeneityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d677138c-fd2e-4978-8390-263033da5570EnglishSymplectic ElementsCell Press2021Washer, SJBassett, ARCowley, SAYoung et al. examine the complexity of primary human microglia, and identify previously unknown cell states. Using expression quantitative trait locus (eQTL) mapping techniques, they identify 129 genes whose expression in microglia is linked to disease, and show that induced pluripotent stem cell (iPSC) models can be used for functional validation of common genetic mutations in microglia-associated diseases. |
| spellingShingle | Washer, SJ Bassett, AR Cowley, SA Variation on a theme: mapping microglial heterogeneity |
| title | Variation on a theme: mapping microglial heterogeneity |
| title_full | Variation on a theme: mapping microglial heterogeneity |
| title_fullStr | Variation on a theme: mapping microglial heterogeneity |
| title_full_unstemmed | Variation on a theme: mapping microglial heterogeneity |
| title_short | Variation on a theme: mapping microglial heterogeneity |
| title_sort | variation on a theme mapping microglial heterogeneity |
| work_keys_str_mv | AT washersj variationonathememappingmicroglialheterogeneity AT bassettar variationonathememappingmicroglialheterogeneity AT cowleysa variationonathememappingmicroglialheterogeneity |