Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently genera...

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Bibliografske podrobnosti
Main Authors: Elrick, H, Peterson, KA, Willis, BJ, Lanza, DG, Acar, EF, Ryder, EJ, Teboul, L, Kasparek, P, Birling, M, Adams, DJ, Bradley, A, Braun, RE, Brown, SD, Caulder, A, Codner, GF, DeMayo, FJ, Dickinson, ME, Doe, B, Duddy, G, Gertsenstein, M, Goodwin, LO, Hérault, Y, Lintott, LG, Lloyd, KCK
Format: Journal article
Jezik:English
Izdano: Nature Research 2024

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