Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well...
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
BioMed Central
2018
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| _version_ | 1826299069981523968 |
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| author | Chu, C Bancone, G Nosten, F White, N Luzzatto, L |
| author_facet | Chu, C Bancone, G Nosten, F White, N Luzzatto, L |
| author_sort | Chu, C |
| collection | OXFORD |
| description | Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well described in G6PD deficient hemizygous males and homozygous females; and haemolysis in the proportionally more numerous heterozygous females has been documented mainly following consumption of fava beans and more recently dapsone. It has long been known that 8-aminoquinolines, notably primaquine and tafenoquine, cause acute haemolysis in G6PD deficiency. To support wider use of primaquine in Plasmodium vivax elimination, more data are needed on the haemolytic consequences of 8-aminoquinolines in G6PD heterozygous females. Two recent studies (in 2017) have provided precisely such data; and the need has emerged for the development of point of care quantitative testing of G6PD activity. Another priority is exploring alternative 8-aminoquinoline dosing regimens that are practical and improve safety in G6PD deficient individuals. |
| first_indexed | 2024-03-07T04:56:18Z |
| format | Journal article |
| id | oxford-uuid:d6b8936a-e53b-41c3-9f34-1ae33c76ebf3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:56:18Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:d6b8936a-e53b-41c3-9f34-1ae33c76ebf32022-03-27T08:35:45ZPrimaquine-induced haemolysis in females heterozygous for G6PD deficiencyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6b8936a-e53b-41c3-9f34-1ae33c76ebf3EnglishSymplectic Elements at OxfordBioMed Central2018Chu, CBancone, GNosten, FWhite, NLuzzatto, LOxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well described in G6PD deficient hemizygous males and homozygous females; and haemolysis in the proportionally more numerous heterozygous females has been documented mainly following consumption of fava beans and more recently dapsone. It has long been known that 8-aminoquinolines, notably primaquine and tafenoquine, cause acute haemolysis in G6PD deficiency. To support wider use of primaquine in Plasmodium vivax elimination, more data are needed on the haemolytic consequences of 8-aminoquinolines in G6PD heterozygous females. Two recent studies (in 2017) have provided precisely such data; and the need has emerged for the development of point of care quantitative testing of G6PD activity. Another priority is exploring alternative 8-aminoquinoline dosing regimens that are practical and improve safety in G6PD deficient individuals. |
| spellingShingle | Chu, C Bancone, G Nosten, F White, N Luzzatto, L Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title_full | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title_fullStr | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title_full_unstemmed | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title_short | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency |
| title_sort | primaquine induced haemolysis in females heterozygous for g6pd deficiency |
| work_keys_str_mv | AT chuc primaquineinducedhaemolysisinfemalesheterozygousforg6pddeficiency AT banconeg primaquineinducedhaemolysisinfemalesheterozygousforg6pddeficiency AT nostenf primaquineinducedhaemolysisinfemalesheterozygousforg6pddeficiency AT whiten primaquineinducedhaemolysisinfemalesheterozygousforg6pddeficiency AT luzzattol primaquineinducedhaemolysisinfemalesheterozygousforg6pddeficiency |