Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients.
Quantitative morphometry of the pancreases of five 'maturity-onset' diabetic subjects has demonstrated more amyloid in islets of the head, body and tail (where it was found in a mean 29% of the islets occupying a mean 11% islet area) than in islets of the 'pancreatic-polypeptide-rich&...
| Autores principales: | , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
1984
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| _version_ | 1826299088714334208 |
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| author | Clark, A Holman, R Matthews, DR Hockaday, T Turner, R |
| author_facet | Clark, A Holman, R Matthews, DR Hockaday, T Turner, R |
| author_sort | Clark, A |
| collection | OXFORD |
| description | Quantitative morphometry of the pancreases of five 'maturity-onset' diabetic subjects has demonstrated more amyloid in islets of the head, body and tail (where it was found in a mean 29% of the islets occupying a mean 11% islet area) than in islets of the 'pancreatic-polypeptide-rich' lobule of the head (where amyloid was found in a mean of 3% of the islets occupying a mean of 0.7% islet area, both p less than 0.005). The non-uniform amyloid distribution may relate to the hormone content of the islet; the head and tail contained significantly more A, B and D-cells than the pancreatic-polypeptide-rich lobule in both non-diabetic subjects (n = 8) and diabetic patients (n = 5; p less than 0.005). This result is compatible with the previous suggestion that amyloid may be derived from insulin or its precursors. |
| first_indexed | 2024-03-07T04:56:35Z |
| format | Journal article |
| id | oxford-uuid:d6cfe6e4-41ec-4ab5-b2a5-fa513c50f80b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:56:35Z |
| publishDate | 1984 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | oxford-uuid:d6cfe6e4-41ec-4ab5-b2a5-fa513c50f80b2022-03-27T08:36:24ZNon-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6cfe6e4-41ec-4ab5-b2a5-fa513c50f80bEnglishSymplectic Elements at OxfordSpringer-Verlag1984Clark, AHolman, RMatthews, DRHockaday, TTurner, RQuantitative morphometry of the pancreases of five 'maturity-onset' diabetic subjects has demonstrated more amyloid in islets of the head, body and tail (where it was found in a mean 29% of the islets occupying a mean 11% islet area) than in islets of the 'pancreatic-polypeptide-rich' lobule of the head (where amyloid was found in a mean of 3% of the islets occupying a mean of 0.7% islet area, both p less than 0.005). The non-uniform amyloid distribution may relate to the hormone content of the islet; the head and tail contained significantly more A, B and D-cells than the pancreatic-polypeptide-rich lobule in both non-diabetic subjects (n = 8) and diabetic patients (n = 5; p less than 0.005). This result is compatible with the previous suggestion that amyloid may be derived from insulin or its precursors. |
| spellingShingle | Clark, A Holman, R Matthews, DR Hockaday, T Turner, R Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title | Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title_full | Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title_fullStr | Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title_full_unstemmed | Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title_short | Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients. |
| title_sort | non uniform distribution of islet amyloid in the pancreas of maturity onset diabetic patients |
| work_keys_str_mv | AT clarka nonuniformdistributionofisletamyloidinthepancreasofmaturityonsetdiabeticpatients AT holmanr nonuniformdistributionofisletamyloidinthepancreasofmaturityonsetdiabeticpatients AT matthewsdr nonuniformdistributionofisletamyloidinthepancreasofmaturityonsetdiabeticpatients AT hockadayt nonuniformdistributionofisletamyloidinthepancreasofmaturityonsetdiabeticpatients AT turnerr nonuniformdistributionofisletamyloidinthepancreasofmaturityonsetdiabeticpatients |