The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca(2+) influx is differentially controlled by the cytoplasmic C-terminal domains of GluN2B (CTD(2B)) and GluN2A (CTD(2A)). Studying the effects of acute ex...

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Bibliographic Details
Main Authors:	Martel, M, Ryan, T, Bell, K, Fowler, J, McMahon, A, Al-Mubarak, B, Komiyama, N, Horsburgh, K, Kind, P, Grant, S, Wyllie, D, Hardingham, G
Format:	Journal article
Language:	English
Published:	2012

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