Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12.
BACKGROUND: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leuco...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797097522940870656 |
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| author | Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D |
| author_facet | Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D |
| author_sort | Casals-Pascual, C |
| collection | OXFORD |
| description | BACKGROUND: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. METHODS: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual Plasmodium falciparum parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N = 60). RESULTS: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. CONCLUSION: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malarial anaemia. |
| first_indexed | 2024-03-07T04:56:45Z |
| format | Journal article |
| id | oxford-uuid:d6dc6989-f554-430f-a998-b19e3c79a37b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:56:45Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:d6dc6989-f554-430f-a998-b19e3c79a37b2022-03-27T08:36:43ZLactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6dc6989-f554-430f-a998-b19e3c79a37bEnglishSymplectic Elements at Oxford2006Casals-Pascual, CKai, OLowe, BEnglish, MWilliams, TMaitland, KNewton, CPeshu, NRoberts, D BACKGROUND: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. METHODS: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual Plasmodium falciparum parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N = 60). RESULTS: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. CONCLUSION: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malarial anaemia. |
| spellingShingle | Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title_full | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title_fullStr | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title_full_unstemmed | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title_short | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12. |
| title_sort | lactate levels in severe malarial anaemia are associated with haemozoin containing neutrophils and low levels of il 12 |
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