Rhodium(I) catalysis for intermolecular alkyne hydroacylation and desymmetrisation
<p>This thesis discloses the uses and development of rhodium(I) catalysis within intermolecular hydroacylation and asymmetric [2+2+2] cycloadditions.</p> <p><b>Chapter 1</b> provides a general overview of the key methods and tethering strategies within the field rhodiu...
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| Format: | Thesis |
| Language: | English |
| Published: |
2022
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| Summary: | <p>This thesis discloses the uses and development of rhodium(I) catalysis within intermolecular hydroacylation and asymmetric [2+2+2] cycloadditions.</p>
<p><b>Chapter 1</b> provides a general overview of the key methods and tethering strategies within the field rhodium(I) catalysed hydroacylation.</p>
<p><b>Chapter 2</b> describes the diverse synthesis of fully saturated O- and N-heterocycles through a hydroacylation/conjugate-addition sequence.</p>
<p><b>Chapter 3</b> uses azine N-oxides as novel directing groups for aldehyde C–H activation within intermolecular hydroacylation reactions.</p>
<p><b>Chapter 4</b> presents a short field overview of rhodium(I) catalysed [2+2+2] cycloaddition, before applying this reaction to sulfoximine desymmetrisation.</p> |
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