Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.

The pancreatic beta-cell type of ATP-sensitive potassium (KATP) channel (Kir6.2/SUR1) is inhibited by intracellular ATP and ADP, which bind to the Kir6.2 subunit, and is activated by Mg-nucleotide interaction with the regulatory sulphonylurea receptor subunits (SUR1). The nicotinamide adenine dinucl...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Dabrowski, M, Trapp, S, Ashcroft, F
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2003

समान संसाधन

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Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
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The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
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3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.
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A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
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Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
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Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells
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Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
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Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
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Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
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Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
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Dynamic duo: Kir6 and SUR in KATP channel structure and function
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A novel SUR1/Kir6.2 specific K-ATP channel opener
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Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
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Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
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The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.
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Mapping the architecture of the ATP-binding site of Kir6.2
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Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.
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Direct interaction of Na-azide with the KATP channel.
द्वारा: Trapp, S, और अन्य
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Identification of residues contributing to the ATP binding site of Kir6.2.
द्वारा: Trapp, S, और अन्य
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The N-terminus of Kir6.2 is involved in coupling to SUR1
द्वारा: Reimann, F, और अन्य
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Nucleotide modulation of pinacidil stimulation of cloned KATP channels
द्वारा: Reimann, F, और अन्य
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Expression of the cloned beta-cell ATP-sensitive potassium channel in Xenopus oocytes
द्वारा: Gribble, F, और अन्य
प्रकाशित: (1996)

Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.
द्वारा: Sakura, H, और अन्य
प्रकाशित: (1999)

Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
द्वारा: Gloyn, A, और अन्य
प्रकाशित: (2006)

An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.
द्वारा: Craig, T, और अन्य
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The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
द्वारा: Tammaro, P, और अन्य
प्रकाशित: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
द्वारा: Tammaro, P, और अन्य
प्रकाशित: (2007)

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.
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Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
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Expression and Analysis of Flow-regulated Ion Channels in Xenopus Oocytes
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Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
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Molecular determinants of KATP channel inhibition by ATP.
द्वारा: Tucker, S, और अन्य
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Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
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प्रकाशित: (2005)