Complement and renal transplantation: from donor to recipient.
Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However,...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826299118279983104 |
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| author | Damman, J Schuurs, T Ploeg, R Seelen, M |
| author_facet | Damman, J Schuurs, T Ploeg, R Seelen, M |
| author_sort | Damman, J |
| collection | OXFORD |
| description | Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome. |
| first_indexed | 2024-03-07T04:57:03Z |
| format | Journal article |
| id | oxford-uuid:d6f75a1a-dcda-4ce7-8810-dbb5cc95740a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:57:03Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:d6f75a1a-dcda-4ce7-8810-dbb5cc95740a2022-03-27T08:37:28ZComplement and renal transplantation: from donor to recipient.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d6f75a1a-dcda-4ce7-8810-dbb5cc95740aEnglishSymplectic Elements at Oxford2008Damman, JSchuurs, TPloeg, RSeelen, MLong-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome. |
| spellingShingle | Damman, J Schuurs, T Ploeg, R Seelen, M Complement and renal transplantation: from donor to recipient. |
| title | Complement and renal transplantation: from donor to recipient. |
| title_full | Complement and renal transplantation: from donor to recipient. |
| title_fullStr | Complement and renal transplantation: from donor to recipient. |
| title_full_unstemmed | Complement and renal transplantation: from donor to recipient. |
| title_short | Complement and renal transplantation: from donor to recipient. |
| title_sort | complement and renal transplantation from donor to recipient |
| work_keys_str_mv | AT dammanj complementandrenaltransplantationfromdonortorecipient AT schuurst complementandrenaltransplantationfromdonortorecipient AT ploegr complementandrenaltransplantationfromdonortorecipient AT seelenm complementandrenaltransplantationfromdonortorecipient |