Immune recognition. A new receptor for beta-glucans.
The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to recept...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1826299138496528384 |
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| author | Brown, G Gordon, S |
| author_facet | Brown, G Gordon, S |
| author_sort | Brown, G |
| collection | OXFORD |
| description | The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans. |
| first_indexed | 2024-03-07T04:57:22Z |
| format | Journal article |
| id | oxford-uuid:d70f684e-74a6-4686-a038-7ba1a9e57207 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:57:22Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:d70f684e-74a6-4686-a038-7ba1a9e572072022-03-27T08:38:16ZImmune recognition. A new receptor for beta-glucans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d70f684e-74a6-4686-a038-7ba1a9e57207EnglishSymplectic Elements at Oxford2001Brown, GGordon, SThe carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans. |
| spellingShingle | Brown, G Gordon, S Immune recognition. A new receptor for beta-glucans. |
| title | Immune recognition. A new receptor for beta-glucans. |
| title_full | Immune recognition. A new receptor for beta-glucans. |
| title_fullStr | Immune recognition. A new receptor for beta-glucans. |
| title_full_unstemmed | Immune recognition. A new receptor for beta-glucans. |
| title_short | Immune recognition. A new receptor for beta-glucans. |
| title_sort | immune recognition a new receptor for beta glucans |
| work_keys_str_mv | AT browng immunerecognitionanewreceptorforbetaglucans AT gordons immunerecognitionanewreceptorforbetaglucans |