Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

A novel series of 5-amino-1,4-benzodiazepin-2-one derivatives (amidines), which contain a cationic solubilizing group and which are antagonists for the cholecystokinin (CCK)-B receptor, have been identified. Optimization of this series led to the identification of an azabicyclononane amidine, L-740,...

Bibliografske podrobnosti
Main Authors:	Patel, S, Smith, A, Chapman, K, Fletcher, A, Kemp, J, Marshall, G, Hargreaves, R, Ryecroft, W, Iversen, L, Iversen, S
Format:	Journal article
Jezik:	English
Izdano:	1994

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