Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Both the epidermal growth factor (EGF) and the vascular endothelial growth factor (VEGF) pathways are associated with intestinal cancer, and therapeutic approaches targeting either EGF receptor (EGFR) or VEGF receptor (VEGFR) signaling have recently been approved for patients with advanced colorecta...

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Bibliographic Details
Main Authors: Alferez, D, Wilkinson, R, Watkins, J, Poulsom, R, Mandir, N, Wedge, SR, Pyrah, I, Smith, N, Jackson, L, Ryan, A, Goodlad, R
Format: Journal article
Language:English
Published: 2008

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