Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care
N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investiga...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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BMJ Publishing Group
2017
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| _version_ | 1797097592445730816 |
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| author | Hex, C Smeets, M Penders, J Van Hoof, V Verbakel, J Buntinx, F Vaes, B |
| author_facet | Hex, C Smeets, M Penders, J Van Hoof, V Verbakel, J Buntinx, F Vaes, B |
| author_sort | Hex, C |
| collection | OXFORD |
| description | N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investigated the user-friendliness and usefulness of the POC device.Five general practitioner (GP) groups were asked to evaluate adult patients who were suspected of having heart failure and to test NT-proBNP with the Cobas h232. The samples were subsequently delivered to and analysed at a central hospital laboratory by the Cobas e602 using conventional transport and storage. Difference between the paired measurements was analysed using a percentage difference plot, and correlation was assessed using Passing-Bablok linear regression analysis. User-friendliness and usefulness were assessed using semistructured questionnaires.Nineteen GPs studied 94 patients. Passing-Bablok analysis showed a slope of 1.05 (95% CI 1.00 to 1.11) (R2=0.97). The percentage difference plot showed a mean difference of 15.7% (95% CI -46.0% to -77.4%). User-friendliness and usefulness had median scores of 4 or 5 on a five-point Likert scale. Eighteen out of 19 GPs confirmed that the device influenced their clinical practice. During the study, GPs' confidence in using NT-proBNP increased significantly from a mean score of 4.4 (95% CI 3.2 to 5.6) to 7.6 out of 10 (95% CI 7.1 to 8.2).The Cobas h232 NT-proBNP POC test proved to be an accurate, user-friendly and useful test in primary care. Nearly all participating GPs were convinced that the test could benefit clinical decision making. |
| first_indexed | 2024-03-07T04:57:47Z |
| format | Journal article |
| id | oxford-uuid:d73015a8-e230-48dd-80e0-7f18c4d7240d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:57:47Z |
| publishDate | 2017 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:d73015a8-e230-48dd-80e0-7f18c4d7240d2022-03-27T08:39:20ZAccuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary careJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d73015a8-e230-48dd-80e0-7f18c4d7240dEnglishSymplectic Elements at OxfordBMJ Publishing Group2017Hex, CSmeets, MPenders, JVan Hoof, VVerbakel, JBuntinx, FVaes, BN-terminal pro-B-type natriuretic peptide (NT-proBNP) has been shown to be useful for ruling out heart failure in primary care. In this study, we examined the accuracy of the Cobas h232 point-of-care (POC) instrument in primary care compared with an in-hospital measurement. Furthermore, we investigated the user-friendliness and usefulness of the POC device.Five general practitioner (GP) groups were asked to evaluate adult patients who were suspected of having heart failure and to test NT-proBNP with the Cobas h232. The samples were subsequently delivered to and analysed at a central hospital laboratory by the Cobas e602 using conventional transport and storage. Difference between the paired measurements was analysed using a percentage difference plot, and correlation was assessed using Passing-Bablok linear regression analysis. User-friendliness and usefulness were assessed using semistructured questionnaires.Nineteen GPs studied 94 patients. Passing-Bablok analysis showed a slope of 1.05 (95% CI 1.00 to 1.11) (R2=0.97). The percentage difference plot showed a mean difference of 15.7% (95% CI -46.0% to -77.4%). User-friendliness and usefulness had median scores of 4 or 5 on a five-point Likert scale. Eighteen out of 19 GPs confirmed that the device influenced their clinical practice. During the study, GPs' confidence in using NT-proBNP increased significantly from a mean score of 4.4 (95% CI 3.2 to 5.6) to 7.6 out of 10 (95% CI 7.1 to 8.2).The Cobas h232 NT-proBNP POC test proved to be an accurate, user-friendly and useful test in primary care. Nearly all participating GPs were convinced that the test could benefit clinical decision making. |
| spellingShingle | Hex, C Smeets, M Penders, J Van Hoof, V Verbakel, J Buntinx, F Vaes, B Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title | Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title_full | Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title_fullStr | Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title_full_unstemmed | Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title_short | Accuracy, user-friendliness and usefulness of the Cobas h232 point-of-care test for NT-proBNP in primary care |
| title_sort | accuracy user friendliness and usefulness of the cobas h232 point of care test for nt probnp in primary care |
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