BEARscc determines robustness of single-cell clusters using simulated technical replicates

<p>Single cell messenger RNA sequencing (scRNA-seq) has emerged as a powerful tool to study cellular heterogeneity within complex tissues. Subpopulations of cells with common gene expression profiles can be identified by applying unsupervised clustering algorithms. However, technical variance...

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Bibliographic Details
Main Authors: Severson, D, Owen, R, White, M, Lu, X, Schuster-Boeckler, P
Format: Journal article
Published: Nature Publishing Group 2018