T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.

Environmental factors account for 75% of the risk of developing multiple sclerosis (MS). Numerous infections have been suspected as environmental disease triggers, but none of them has consistently been incriminated, and it is unclear how so many different infections may play a role. We show that a...

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Détails bibliographiques
Auteurs principaux: Harkiolaki, M, Holmes, S, Svendsen, P, Gregersen, J, Jensen, LT, McMahon, R, Friese, M, van Boxel, G, Etzensperger, R, Tzartos, J, Kranc, K, Sainsbury, S, Harlos, K, Mellins, E, Palace, J, Esiri, M, Van Der Merwe, P, Jones, E, Fugger, L
Format: Journal article
Langue:English
Publié: 2009