Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

अन्य संस्करण दिखाएं (1)

Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant and amnestic properties. Recently triazolo-benzodiazepines have been also described as potent and highly selective protein interaction inhibitors of bromodomain and extra-terminal (BET) proteins, a family of t...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Filippakopoulos, P, Picaud, S, Fedorov, O, Keller, M, Wrobel, M, Morgenstern, O, Bracher, F, Knapp, S
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2012

समान संसाधन

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2012)

The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
द्वारा: Hay, D, और अन्य
प्रकाशित: (2013)

Chemical probes for bromodomains outside the BET family
द्वारा: Brennan, P, और अन्य
प्रकाशित: (2013)

Developing chemical probes for the BET bromodomains
द्वारा: Hewings, D, और अन्य
प्रकाशित: (2012)

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.
द्वारा: Picaud, S, और अन्य
प्रकाशित: (2013)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
द्वारा: Picaud, S, और अन्य
प्रकाशित: (2013)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
द्वारा: Picaud, S, और अन्य
प्रकाशित: (2013)

Selective inhibition of BET bromodomains.
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2010)

Selective inhibition of BET bromodomains.
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2010)

Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.
द्वारा: Kempen, H, और अन्य
प्रकाशित: (2013)

Discovery of BET bromodomain inhibitors and their role in target validation
द्वारा: Mueller, S, और अन्य
प्रकाशित: (2014)

Synthesis and biological investigation of (+)-JD1, an organometallic BET bromodomain inhibitor
द्वारा: Hassell-Hart, S, और अन्य
प्रकाशित: (2019)

Interactome rewiring following pharmacological targeting of BET bromodomains
द्वारा: Lambert, J-P, और अन्य
प्रकाशित: (2018)

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
द्वारा: Philpott, M, और अन्य
प्रकाशित: (2011)

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
द्वारा: Philpott, M, और अन्य
प्रकाशित: (2011)

Chemical probes and inhibitors of bromodomains outside the BET family
द्वारा: Moustakim, M, और अन्य
प्रकाशित: (2016)

Evaluation of linker length effects on a BET bromodomain probe
द्वारा: Traquete, R, और अन्य
प्रकाशित: (2019)

Promiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
द्वारा: Picaud, S, और अन्य
प्रकाशित: (2016)

Bromodomains as therapeutic targets.
द्वारा: Muller, S, और अन्य
प्रकाशित: (2011)

Small-molecule bromodomain inhibitors for cancer therapy
द्वारा: Qi, J, और अन्य
प्रकाशित: (2010)

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
द्वारा: Ciceri, P, और अन्य
प्रकाशित: (2014)

Targeting bromodomains: epigenetic readers of lysine acetylation.
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2014)

Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma
द्वारा: Cheng, Z, और अन्य
प्रकाशित: (2013)

Inhibition of BET bromodomain targets genetically diverse glioblastoma.
द्वारा: Cheng, Z, और अन्य
प्रकाशित: (2013)

Corrigendum: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
द्वारा: Ciceri, P, और अन्य
प्रकाशित: (2014)

Effect of BET missense mutations on bromodomain function, inhibitor binding and stability
द्वारा: Lori, L, और अन्य
प्रकाशित: (2016)

Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
द्वारा: Popp, T, और अन्य
प्रकाशित: (2016)

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.
द्वारा: Laura Lori, और अन्य
प्रकाशित: (2016-01-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
द्वारा: Jennings, L, और अन्य
प्रकाशित: (2018)

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.
द्वारा: Fedorov, O, और अन्य
प्रकाशित: (2014)

The bromodomain interaction module.
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2012)

The bromodomain interaction module
द्वारा: Filippakopoulos, P, और अन्य
प्रकाशित: (2012)

Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction
द्वारा: Rooney, T, और अन्य
प्रकाशित: (2012)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
द्वारा: Hewings, D, और अन्य
प्रकाशित: (2011)

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
द्वारा: Chaidos, A, और अन्य
प्रकाशित: (2014)

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1
द्वारा: Meropi Bagka, और अन्य
प्रकाशित: (2023-07-01)

3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interaction
द्वारा: Hewings, D, और अन्य
प्रकाशित: (2012)

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
द्वारा: Alison M. Kurimchak, और अन्य
प्रकाशित: (2016-08-01)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
द्वारा: Kenneth K. W. To, और अन्य
प्रकाशित: (2023-03-01)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
द्वारा: Hewings, D, और अन्य
प्रकाशित: (2011)