Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

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Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant and amnestic properties. Recently triazolo-benzodiazepines have been also described as potent and highly selective protein interaction inhibitors of bromodomain and extra-terminal (BET) proteins, a family of t...

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Main Authors:	Filippakopoulos, P, Picaud, S, Fedorov, O, Keller, M, Wrobel, M, Morgenstern, O, Bracher, F, Knapp, S
格式:	Journal article
语言:	English
出版:	2012

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