XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations inXIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAPo...

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Bibliographic Details
Main Authors: Yabal, M, Müller, N, Adler, H, Knies, N, Groß, C, Damgaard, R, Kanegane, H, Ringelhan, M, Kaufmann, T, Heikenwälder, M, Strasser, A, Groß, O, Ruland, J, Peschel, C, Gyrd-Hansen, M, Jost, P
Format: Journal article
Language:English
Published: Elsevier 2014