XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations inXIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAPo...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
Elsevier
2014
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