Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA.

FtsK is a homohexameric, RecA-like dsDNA translocase that plays a key role in bacterial chromosome segregation. The FtsK regulatory γ-subdomain determines directionality of translocation through its interaction with specific 8 base pair chromosomal sequences [(KOPS); FtsK Orienting/Polarizing Sequen...

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Main Authors: Graham, J, Sherratt, D, Szczelkun, MD
格式: Journal article
语言:English
出版: 2010