Host control and the evolution of cooperation in host microbiomes
Humans, and many other species, are host to diverse symbionts. It is often suggested that the mutual benefits of host-microbe relationships can alone explain cooperative evolution. Here, we evaluate this hypothesis with evolutionary modelling. Our model predicts that mutual benefits are insufficient...
| Main Authors: | , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Springer Nature
2022
|
| _version_ | 1826308913224482816 |
|---|---|
| author | Sharp, C Foster, KR |
| author_facet | Sharp, C Foster, KR |
| author_sort | Sharp, C |
| collection | OXFORD |
| description | Humans, and many other species, are host to diverse symbionts. It is often suggested that the mutual benefits of host-microbe relationships can alone explain cooperative evolution. Here, we evaluate this hypothesis with evolutionary modelling. Our model predicts that mutual benefits are insufficient to drive cooperation in systems like the human microbiome, because of competition between symbionts. However, cooperation can emerge if hosts can exert control over symbionts, so long as there are constraints that limit symbiont counter evolution. We test our model with genomic data of two bacterial traits monitored by animal immune systems. In both cases, bacteria have evolved as predicted under host control, tending to lose flagella and maintain butyrate production when host-associated. Moreover, an analysis of bacteria that retain flagella supports the evolution of host control, via toll-like receptor 5, which limits symbiont counter evolution. Our work puts host control mechanisms, including the immune system, at the centre of microbiome evolution. |
| first_indexed | 2024-03-07T07:26:17Z |
| format | Journal article |
| id | oxford-uuid:d77844f3-9217-4057-a142-fe7cc2f4b513 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:26:17Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:d77844f3-9217-4057-a142-fe7cc2f4b5132022-11-22T07:31:14ZHost control and the evolution of cooperation in host microbiomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d77844f3-9217-4057-a142-fe7cc2f4b513EnglishSymplectic ElementsSpringer Nature2022Sharp, CFoster, KRHumans, and many other species, are host to diverse symbionts. It is often suggested that the mutual benefits of host-microbe relationships can alone explain cooperative evolution. Here, we evaluate this hypothesis with evolutionary modelling. Our model predicts that mutual benefits are insufficient to drive cooperation in systems like the human microbiome, because of competition between symbionts. However, cooperation can emerge if hosts can exert control over symbionts, so long as there are constraints that limit symbiont counter evolution. We test our model with genomic data of two bacterial traits monitored by animal immune systems. In both cases, bacteria have evolved as predicted under host control, tending to lose flagella and maintain butyrate production when host-associated. Moreover, an analysis of bacteria that retain flagella supports the evolution of host control, via toll-like receptor 5, which limits symbiont counter evolution. Our work puts host control mechanisms, including the immune system, at the centre of microbiome evolution. |
| spellingShingle | Sharp, C Foster, KR Host control and the evolution of cooperation in host microbiomes |
| title | Host control and the evolution of cooperation in host microbiomes |
| title_full | Host control and the evolution of cooperation in host microbiomes |
| title_fullStr | Host control and the evolution of cooperation in host microbiomes |
| title_full_unstemmed | Host control and the evolution of cooperation in host microbiomes |
| title_short | Host control and the evolution of cooperation in host microbiomes |
| title_sort | host control and the evolution of cooperation in host microbiomes |
| work_keys_str_mv | AT sharpc hostcontrolandtheevolutionofcooperationinhostmicrobiomes AT fosterkr hostcontrolandtheevolutionofcooperationinhostmicrobiomes |