Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer treatment modality; however, neoantigen physicochemical variability can present challenges to manufacturing personalized cancer vaccines in an optimal format for inducing anticancer T cells. Here, we developed...

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Bibliographic Details
Main Authors: Lynn, GM, Sedlik, C, Baharom, F, Zhu, Y, Ramirez-Valdez, RA, Coble, VL, Tobin, K, Nichols, SR, Itzkowitz, Y, Zaidi, N, Gammon, JM, Blobel, NJ, Denizeau, J, de la Rochere, P, Francica, BJ, Decker, B, Maciejewski, M, Cheung, J, Yamane, H, Smelkinson, MG, Francica, JR, Laga, R, Bernstock, JD, Seymour, LW, Drake, CG, Jewell, CM, Lantz, O, Piaggio, E, Ishizuka, AS, Seder, RA
Format: Journal article
Language:English
Published: Nature Research 2020

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