Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
The instability of DNA triplexes particularly at neutral pH and above severely limits their applications. Here, we demonstrate that the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs) resolves this problem. The stabilising effe...
| Glavni autori: | , , |
|---|---|
| Format: | Journal article |
| Izdano: |
Royal Society of Chemistry
2018
|