Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

The instability of DNA triplexes particularly at neutral pH and above severely limits their applications. Here, we demonstrate that the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs) resolves this problem. The stabilising effe...

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Bibliografische gegevens
Hoofdauteurs:	Walsh, S, El-Sagheer, A, Brown, T
Formaat:	Journal article
Gepubliceerd in:	Royal Society of Chemistry 2018

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