Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants...
| मुख्य लेखकों: | , , , , , , , , , , , , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2009
|
| _version_ | 1826299251709181952 |
|---|---|
| author | Atwal, G Kirchhoff, T Bond, E Montagna, M Monagna, M Menin, C Bertorelle, R Scaini, M Bartel, F Böhnke, A Pempe, C Gradhand, E Hauptmann, S Offit, K Levine, A Bond, G |
| author_facet | Atwal, G Kirchhoff, T Bond, E Montagna, M Monagna, M Menin, C Bertorelle, R Scaini, M Bartel, F Böhnke, A Pempe, C Gradhand, E Hauptmann, S Offit, K Levine, A Bond, G |
| author_sort | Atwal, G |
| collection | OXFORD |
| description | A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants in p53 and MDM2 have shown that single nucleotide polymorphisms (SNPs) can affect p53 signaling, confer cancer risk, and suggest that the pathway is under evolutionary selective pressure (1-4). In this report, we analyze the haplotype structure of MDM4, a structural homolog of MDM2, in several different human populations. Unusual patterns of linkage disequilibrium (LD) in the haplotype distribution of MDM4 indicate the presence of candidate SNPs that may also modify the efficacy of the p53 pathway. Association studies in 5 different patient populations reveal that these SNPs in MDM4 confer an increased risk for, or early onset of, human breast and ovarian cancers in Ashkenazi Jewish and European cohorts, respectively. This report not only implicates MDM4 as a key regulator of tumorigenesis in the human breast and ovary, but also exploits for the first time evolutionary driven linkage disequilibrium as a means to select SNPs of p53 pathway genes that might be clinically relevant. |
| first_indexed | 2024-03-07T04:59:05Z |
| format | Journal article |
| id | oxford-uuid:d7a3e056-e338-44b8-9a38-fbb92f8e0939 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:59:05Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:d7a3e056-e338-44b8-9a38-fbb92f8e09392022-03-27T08:42:35ZAltered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d7a3e056-e338-44b8-9a38-fbb92f8e0939EnglishSymplectic Elements at Oxford2009Atwal, GKirchhoff, TBond, EMontagna, MMonagna, MMenin, CBertorelle, RScaini, MBartel, FBöhnke, APempe, CGradhand, EHauptmann, SOffit, KLevine, ABond, GA large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants in p53 and MDM2 have shown that single nucleotide polymorphisms (SNPs) can affect p53 signaling, confer cancer risk, and suggest that the pathway is under evolutionary selective pressure (1-4). In this report, we analyze the haplotype structure of MDM4, a structural homolog of MDM2, in several different human populations. Unusual patterns of linkage disequilibrium (LD) in the haplotype distribution of MDM4 indicate the presence of candidate SNPs that may also modify the efficacy of the p53 pathway. Association studies in 5 different patient populations reveal that these SNPs in MDM4 confer an increased risk for, or early onset of, human breast and ovarian cancers in Ashkenazi Jewish and European cohorts, respectively. This report not only implicates MDM4 as a key regulator of tumorigenesis in the human breast and ovary, but also exploits for the first time evolutionary driven linkage disequilibrium as a means to select SNPs of p53 pathway genes that might be clinically relevant. |
| spellingShingle | Atwal, G Kirchhoff, T Bond, E Montagna, M Monagna, M Menin, C Bertorelle, R Scaini, M Bartel, F Böhnke, A Pempe, C Gradhand, E Hauptmann, S Offit, K Levine, A Bond, G Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title_full | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title_fullStr | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title_full_unstemmed | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title_short | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. |
| title_sort | altered tumor formation and evolutionary selection of genetic variants in the human mdm4 oncogene |
| work_keys_str_mv | AT atwalg alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT kirchhofft alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT bonde alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT montagnam alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT monagnam alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT meninc alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT bertoreller alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT scainim alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT bartelf alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT bohnkea alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT pempec alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT gradhande alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT hauptmanns alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT offitk alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT levinea alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene AT bondg alteredtumorformationandevolutionaryselectionofgeneticvariantsinthehumanmdm4oncogene |