Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.

A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants...

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Detalles Bibliográficos
Main Authors: Atwal, G, Kirchhoff, T, Bond, E, Montagna, M, Monagna, M, Menin, C, Bertorelle, R, Scaini, M, Bartel, F, Böhnke, A, Pempe, C, Gradhand, E, Hauptmann, S, Offit, K, Levine, A, Bond, G
Formato: Journal article
Idioma:English
Publicado: 2009

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